it's unfortunately very possible. one way is to not drive it a long time, same as a gas-only / non-hybrid vehicle.Unless I am missing something with the hybrids it shouldn't be possible to discharge a 12v battery to the point you can't start the truck. They like the Ecoboosts have an BMS (Battery Management System/Sensor) that will cut off all electrical inputs into the batttery when the battery voltage drops to a certain level. Unless you wire around it or there is some defect in the BMS itself a parasitic drain or any outlet in use with the key off can not take down the battery. If the 12V battery is losing charge to the point you can't start the truck it is most likely the battery itself.
the other 2 ways are issues with the charging system. there was a cable issue TSB last year and by this point, all trucks should be fixed if they were affected. and then there's a second TSB just issued last month (or maybe April) where the 300A fuse which controls the connection between the high voltage battery and the 12V battery can look fine on visual inspection but actually test open (failed). when it's open the HV system can't charge the 12V battery.
if anyone gets deep sleep, either ecoboost or hybrid maverick, the first thing to do is the battery monitoring system reset. it's in the manual and several youtube videos exist. it takes 30 seconds or less and for my truck, it fixed deep sleep.
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